Dosage and Administration Leave a Comment / By veko@Wordpress / October 17, 2023 Once a month, at the recommended minimum dosage of0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10mg/kg) lufenuron. For dogs over 100 lb / 45 Kgs use the appropriate combination Or as directed by the Veterinarian.